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Visualizing simulated electrical fields from electroencephalography and transcranial electric brain stimulation: A comparative evaluation

机译:可视化脑电图和经颅电脑刺激的模拟电场:比较评估

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摘要

Electrical activity of neuronal populations is a crucial aspect of brain activity. This activity is not measured directly but recorded as electrical potential changes using head surface electrodes (electroencephalogram - EEG). Head surface electrodes can also be deployed to inject electrical currents in order to modulate brain activity (transcranial electric stimulation techniques) for therapeutic and neuroscientific purposes. In electroencephalography and noninvasive electric brain stimulation, electrical fields mediate between electrical signal sources and regions of interest (ROI). These fields can be very complicated in structure, and are influenced in a complex way by the conductivity profile of the human head. Visualization techniques play a central role to grasp the nature of those fields because such techniques allow for an effective conveyance of complex data and enable quick qualitative and quantitative assessments. The examination of volume conduction effects of particular head model parameterizations (e.g., skull thickness and layering), of brain anomalies (e.g., holes in the skull, tumors), location and extent of active brain areas (e.g., high concentrations of current densities) and around current injecting electrodes can be investigated using visualization. Here, we evaluate a number of widely used visualization techniques, based on either the potential distribution or on the current-flow. In particular, we focus on the extractability of quantitative and qualitative information from the obtained images, their effective integration of anatomical context information, and their interaction. We present illustrative examples from clinically and neuroscientifically relevant cases and discuss the pros and cons of the various visualization techniques.
机译:神经元群体的电活动是大脑活动的关键方面。该活性不是直接测量的,而是使用头表面电极记录为电位变化(脑电图-EEG)。头部表面电极也可以被部署以注入电流,以调节大脑活动(经颅电刺激技术),以达到治疗和神经科学的目的。在脑电图和无创性脑电刺激中,电场在电信号源和感兴趣区域(ROI)之间进行调节。这些场在结构上可能非常复杂,并且受到人头的电导率分布图的复杂影响。可视化技术在掌握这些领域的本质方面起着核心作用,因为这种技术可以有效地传达复杂的数据,并可以进行快速的定性和定量评估。检查特定头部模型参数化(例如,颅骨的厚度和分层),大脑异常(例如,颅骨的洞,肿瘤),活动的大脑区域的位置和范围(例如,高密度的电流密度)的体积传导效应可以使用可视化技术研究电流注入电极的周围和周围。在这里,我们根据电位分布或电流来评估多种广泛使用的可视化技术。特别是,我们专注于从获得的图像中提取定量和定性信息,它们对解剖上下文信息的有效整合以及它们之间的相互作用。我们从临床和神经科学方面的相关案例中提供示例性示例,并讨论各种可视化技术的利弊。

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